While synthetic data hold great promise for privacy protection, their statistical analysis poses significant challenges that necessitate innovative solutions.

Choosing relevant predictors is central to the analysis of biomedical time-to-event data. Classical frequentist inference, however, presumes that the set of covariates is fixed in advance and does not account for data-driven variable selection. As a consequence, naive post-selection inference may be biased and misleading. In right-censored survival settings, these issues may be further exacerbated by the additional uncertainty induced by censoring. We investigate several inference procedures applied after variable selection for the coefficients of the Lasso and its extension, the adaptive Lasso, in the context of the Cox model. The methods considered include sample splitting, exact post-selection inference, and the debiased Lasso. Their performance is examined in a neutral simulation study reflecting realistic covariate structures and censoring rates commonly encountered in biomedical applications. To complement the simulation results, we illustrate the practical behavior of these procedures in an applied example using a publicly available survival dataset.

We provide theoretical guarantees, verify robustness in a simulation study, and validate the scalability andusefulness ofourprocedure inareal-worldexperiment onalarge socialnetwork.

Neural networks have shown state-of-the-art performances in various classification and regression tasks. Rectified linear units (ReLU) are often used as activation functions for the hidden layers in a neural network model. In this article, we establish the connection between the Poisson hyperplane processes (PHP) and two-layer ReLU neural networks. We show that the PHP with a Gaussian prior is an alternative probabilistic representation to a two-layer ReLU neural network. In addition, we show that a two-layer neural network constructed by PHP is scalable to large-scale problems via the decomposition propositions. Finally, we propose an annealed sequential Monte Carlo algorithm for Bayesian inference. Our numerical experiments demonstrate that our proposed method outperforms the classic two-layer ReLU neural network. The implementation of our proposed model is available at https://github.com/ShufeiGe/Pois_Relu.git.

We present a new method for linear and nonlinear, lagged and contemporaneous constraint-based causal discovery from observational time series in the presence of latent confounders. We show that existing causal discovery methods such as FCI and variants suffer from low recall in the autocorrelated time series case and identify low effect size of conditional independence tests as the main reason. Information-theoretical arguments show that effect size can often be increased if causal parents are included in the conditioning sets. To identify parents early on, we suggest an iterative procedure that utilizes novel orientation rules to determine ancestral relationships already during the edge removal phase. We prove that the method is order-independent, and sound and complete in the oracle case. Extensive simulation studies for different numbers of variables, time lags, sample sizes, and further cases demonstrate that our method indeed achieves much higher recall than existing methods for the case of autocorrelated continuous variables while keeping false positives at the desired level. This performance gain grows with stronger autocorrelation.

Mobile health leverages personalized and contextually tailored interventions optimized through bandit and reinforcement learning algorithms.

To address this issue, we propose a novel Covariate Shift Corrected Pearson Chi-squared Conditional Randomization (csPCR) test.